Founded in 1743 by Benjamin Franklin, the American Philosophical Society was the first learned society in the United States. For over 250 years, the Society has played an important role in American cultural and intellectual life. Until the mid-nineteenth century, the Society fulfilled the role of a national academy of science, national library and museum, and even patent office. Early members of the Society included Thomas Jefferson, David Rittenhouse, Benjamin Rush, Stephen Peter Du Ponceau, George Washington, and many other figures prominent in American history. The Archives of the American Philosophical Society consists of 192.25 linear feet of material, organized into thirteen record groups dating back to 1743. The Society's archives extensively documents not only the organization's historical development but also its role in American history and the history of science and technology.

The collection of about 850 items covers the period from 1782 to c. 1936, with the bulk dating to the 1780s to 1840s. The collection is divided into four series. Series I contains correspondence relating to a wide variety of topics, including French and English politics, business, trade, religious matters, and personal affairs. Many of the items are letters of introduction. There is also information on John Vaughan's immigration to America, Joseph Priestley, vaccines and inoculation (with Jefferson's comments on the same), Vaughan's business in Philadelphia, and the American Philosophical Society. Also included in this series are 2 boxes with copies of Vaughan correspondence as well as miscellaneous notes by E. W. Madeira, gathered in the course of his research on Vaughan in the 1930s. Series II consists of three volumes. Included are two of Vaughan's commonplace books. One, entitled, "J. Vaughan's book," May 17, 1779 (47 pp., in Latin; 870/L34), includes mostly Latin notations. The other commonplace book, dated 1783 (ca. 66 pp.; B V 462.c), includes comments on several prominent Americans, such as Benjamin Rush and David Rittenhouse, as well as American society generally. The third volume is a copybook with thirty letters spanning the period 1784 to 1801 (B V462.1). Series III includes material relating to Vaughan's administration of the estate of the Philadelphia merchant Samuel Merrick, 1796-1822 (Vaughan-Merrick Papers, B V462.m; 2 boxes). Series IV consists of correspondence between Vaughan and the DuPont Co. for which he served as agent (B V462.4; photocopies of 73 letters).